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Long-Chain Acyl-CoA Synthetase Activity in Blood Platelets and Some Human Tissues

1973; Taylor & Francis; Volume: 31; Issue: 2 Linguagem: Inglês

10.3109/00365517309084311

1502-7686

M. Farstad, Magne Aas, J. Sander,

Liver Disease Diagnosis and Treatment

AbstractThe substrate specificity of long-chain acyl-CoA synthetase activity in human platelets, liver, and adrenal gland have been studied. Human platelets contain one long-chain acyl-CoA synthetase showing optimal activity with palmitate as substrate, whereas both liver and adrenal gland seem to contain two synthetases, one with optimal activity with laurate and one with palmitate. The long-chain acyl-CoA synthetase in both platelets and liver is located in the mitochondria and the microsomal fraction.Key Words: Acyl-CoA synthetase propertiesadrenal glandhumanblood plateletshumanliverhumanmarker enzymessubcellular fractions