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T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior #

1989; Wiley; Volume: 107; Issue: 1 Linguagem: Inglês

10.1111/j.1600-065x.1989.tb00003.x

1600-065X

Charles A. Janeway, Junji Yagi, Patricia J. Conrad, Michael Katz, Barry Jones, Steven M. Vroegop, Stephen Buxser,

Immunotherapy and Immune Responses

Immunological ReviewsVolume 107, Issue 1 p. 61-88 T-Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior# Charles A. Janeway Jr., Charles A. Janeway Jr. Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorJunji Yagi, Junji Yagi Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorPatricia J. Conrad, Patricia J. Conrad Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorMichael E. Katz, Michael E. Katz Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorBarry Jones, Barry Jones Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510 Department of Molecular and Cell Biology, Pennsylvania State University, State College, PA, U.S.A.Search for more papers by this authorSteven Vroegop, Steven Vroegop The Department of Cell Biology, The Upjohn Company, Kalamazoo, MISearch for more papers by this authorStephen Buxser, Stephen Buxser The Department of Cell Biology, The Upjohn Company, Kalamazoo, MISearch for more papers by this author Charles A. Janeway Jr., Charles A. Janeway Jr. Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorJunji Yagi, Junji Yagi Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorPatricia J. Conrad, Patricia J. Conrad Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorMichael E. Katz, Michael E. Katz Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510Search for more papers by this authorBarry Jones, Barry Jones Section of Immunobiology, Howard Hughes Medical Institute at Yale University School of Medicine, New Haven, CT 06510 Department of Molecular and Cell Biology, Pennsylvania State University, State College, PA, U.S.A.Search for more papers by this authorSteven Vroegop, Steven Vroegop The Department of Cell Biology, The Upjohn Company, Kalamazoo, MISearch for more papers by this authorStephen Buxser, Stephen Buxser The Department of Cell Biology, The Upjohn Company, Kalamazoo, MISearch for more papers by this author First published: February 1989 https://doi.org/10.1111/j.1600-065X.1989.tb00003.xCitations: 257 # Supported by NIH grant AI-14579 and the Howard Hughes Medical Institute. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Abe, R. & Hodes, R. (1988) The Mls system: Non-MHC genes that encode strong T-cell stimulatory determinants. Immunology Today 9, 230. Abe, R., Ryan, J. J., Finkelman, F. D. & Hodes, R. J. (1987a) T cell recognition of Mls: T cell clones demonstrate polymorphism between Mlsa. Misc, and Mlsd J. Immunol 138, 373. Abe, R., Ryan, J. J. & Hodes, R.J. (1987b) Clonal analysis of the Mls system. A reappraisal of polymorphism and allelism among Mlsa. Misc, and Mlsd. J. Exp. Med. 165, 1150. Abromsom-Leeman, S. & Cantor, H. (1983) Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products. J. Exp. Med. 158, 428. Ashwell, J. D., Chen, C. & Schwartz, R. H. (1986) High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules. J. Immunol. 136, 389. Babbitt, B. P., Allen, P M., Matsueda, G., Haber, E. & Unanue, E. R. (1985) Binding of an immunogenic peptide to la histocompatibility molecules. Nature 317, 359. Bekoff, M. C, Cole, B. C. & Grey, H. M. (1988) Studies on the mechanism of stimulation of T cells by the Mycoplasma arthritidis-derived mitogen: Role of class II IE molecules. J. Immunol. 139, 3189. Bergdoll, M. S. (1972) The enterotoxins. In: The Staphylococci. J. O. Cohen, ed. Academic Press, New York . 301–331. Bergdoll, M. S. (1983) Enterotoxins. In: Staphylococci and Staphylococcal Infections, Vol. 11. C. S. F. Easman & C. Adiam eds. Academic Press, New York . 559–598. Bjorkman, P. J., Saper, M. A., Sararaoui, B., Bennett, W. S., Strominger, J. L. & Wiley, D. C. (1987a) Structure of the human class I histocorapatibility antigen, HLA-A2. Nature 329, 506. Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L. & Wiley, D. C. (1987b) The foreign antigen binding site and T cell recognition regions of class I histocompatibilily antigens. Nature 329, 512. Blomster-Hautamaa, D. A., Kreiswirth, B. N., Kornblum, J. S., Novick, R. P. & Schlievert, P. M. (1986) The nucleotide and partial amino acid sequence of loxic shock syndrome toxin-1. J. Biol. Chem. 261, 15783. Brown, J. H., Jardetzky, T., Saper, M. A., Bamraoui, B., Bjorkman, P. J. & Wiley, D. C. (1988) A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 332, 845. G. Butcher, ed. (1988) The Mls locus. J. Immunogenetics 15, (in press). Buxser, S. & Vroegop, S. (1988) Staphylococcal enterotoxin B stimulation of BALB/c lymphocyte mitogenesis and potential relationship to the Mls response. J. Immunogenetics 15, (in press). Click, R. E., Adelmann, A. M. & Azar, M. M. (1985) Immune responses in vitro. XlXl. MLR detectability of Mlsa, Mlsb. Mlsc, and Mlsd encoded products. J. Immunol. 128, 1502. Click, R. E., Schneider, D., Sitzmann, L. A. & Azar, M. M. (1984) Immune responses in vitro. XIV. Undeteectability of Mlsb and Mlsc encoded products on FI cells possessing Mls' or A/y. Immunogenetics 20, 301. Cole, B. C, Daynes, R. A. & Ward, J. R. (1981) Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. I. Transformation is associated with an H-2-linked gene that maps to the IE/IC subregion. J. Immunol 127, 1931. Davis, M. M. & Bjorkman, P. J. (1988) T cell antigen receptor genes and T cell recognition. Nature 34, 395. Debreuil, P. C, Caillol, D. H. & Lemonnier, F. A. (1982) Analysis of unexpected inhibitions of T lymphocyte proliferation to soluble antigen, alloantigen and mitogen by unfragmented anti-I-Ak or anti-I-E/Ck monoclonal antibodies. J. Immunogenetics 9, 11. Festenstein, H. (1973) Immunogenetic and biological aspects of in vitro lymphocyte allo-transformation (MLR) in the mouse. Transplant, Rev. 15, 62. Fleischer, B. & Schrezenmeier, H. (1988) T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J. Exp, Med. 167, 1697. Francolins, B. & Klein, J. (1988) High frequency of Mlsa-reactivity among Ab-restricted, H-Y-specific T cell clones. J. Immunogenetics 15, (in press). Gress, R. E., Wesley, M. N. & Hodes, R. J. (1981) The role of H-2 in T cell recognition at Mls. J. Immunol. 127, 1763. Hammerling, U. & Hoffman, M. K. (1986) The role of the Fc receptor in T cell activation. Scand. J. Immunol 24, 621. Hammering, U., Toulon, M., Chun, M., Palfree, S. & Hoffman, M. K. (1988) Bi-directionality of mixed lymphocyte stimulation (Mls) response. Effects of Mls6 stimulator cells on Mlsa helper cells. J. Immunol. 140, 2543. Huang, I-Y. & Bergdoil, M. S. (1970) The primary structure of staphylococcal enterotoxin B. III. The cyanogen bromide peptides of reduced and aminoethylated enterotoxin, and the complete amino acid sequence. J. Biol, Chem. 245, 3518. Huang, I., Hughes, J. L., Bergdoll, M. S. & Schantz, E. J. (1987) Complete amino acid sequence of staphylococcal enterotoxin A. J. Biol Chem. 262, 7006. Janeway, C. A., Jr. (1976) Specific and non-specific cooperation between M-locus-incompatible T and B cells during adoptive anti-happen antibody responses in mice. Scand. J. Immunol. 5, 593. Janeway, C. A., Jr. (1988) T cell development: Accessories or co-receptors. Nature 335, 208. Janeway, C. A., Jr., Carding, S., Jones, B., Murray, J., Portoles, P., Rasmussen, R., Rojo, J., Saizawa, K., West, J. & Bottomly, K. (1988b) CD4 T cells: Specificity and function Immunol, Rev, 101, 39. Janeway, C. A., Jr., Chalupny, J., Conrad, P. J. & Buxser, S. (1988c) An external stimulus that mimics Mls locus responses. J. Immunogenetics 15, (in press). Janeway, C. A., Jr., Conrad, P. J., Tile, J. P., Jones, B. & Murphy, D. B. (1983) Efficiency of antigen presentation differs in mice differing at the Mlslocus. Nature 306. 80. Janeway, C. A., Jr., Hammerling, U. & Fischer-Lindahl, K. (1988a) The Mls locus: New clues to alingering mystery. Immunology Today 9, 125. Janeway, C. A., Jr. & Katz, M. E. (1985) The immunobiology of the T cell response to Mls locus disparate stimulator cells. I, Unidirectionality, new strain combinations, and the role of la antigens. J. Immunol. 134, 2057. Janeway, C. A., Jr., Lerner, E. A., Conrad, P. J. & Jones, B. (1982) The precision of self and non-self major histocompatibility complex encoeed antigen recognition by cloned T cells. Behring Inst. Mitteilungen 70, 200. Janeway, C. A., Jr., Lerner, E. A., Jason, J. M. & Jones, B. (1980) T lymphocytes responding to Mls locus antigens are Lyt-1+,2-− and I-A restricted. Immunogenetics 10, 481. Johnson, L. P., L'Italien, J. J. & Schlievert, P. M. (1986) Streptococcal pyrogenic exotoxin type A (scarlet fever toxin) is related to Staphylococcus aureus enterotoxin B. Mol. Gen. Genet. 203, 354. Jones, B. & Janeway, C. A., Jr. (1982) MHC recognition by clones of Mls specific T lymphocytes. Immunogenetics 16, 243. Jozefzcyk, Z. (1974) Specific human antibodies to enterotoxins A, B, and C of Staphylococcus: Their increased synthesis in staphylococcal infections. J. Infect. Dis. 130, 1. Kappler, J. W., Roehm, N. & Marrack, P (1987) T cell tolerance by clonal elimination in the thymus. Cell 49, 273. Kappler, J. W, Staerz, U., White, J. & Marrack, P. C. (1988) Self-lolerance eliminates T cells specific for Af/i-modified products of the major histocompatibility complex. Nature 332. 35. Katz, M. E. & Janeway, C. A. Jr. (1985) The immunobiology of T cell responses to Mls locus disparate stimulator cells. II. Effects of Mls locus disparate stimulator cells on cloned, protein antigen specific, la restricted T cell lines. J. Immunol. 134, 2064. Katz, M. E., Tile, J. P. & Janeway, C. A., Jr. (1986) The immunobiology of T cell responses to Mls locus disparate stimulator cells. III. Helper and cytolytic functions of cloned, Mls-reactive T cell lines. J. Immunol. 136, 1. Kaye, J. & Janeway, C. A., Jr. (1984) The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide linked heterodimer from a helper T cell clone blocks activation by either allogeneic la or antigen and self Ia. J. Exp. Med. 159. 1397. Lee, A. C-M., Robbins, R. N. & Bergdoll, M. S. (1978) Isolation of specific and common antibodies lo staphylococcal enterotoxins A and E by affinity chromatography. Infect. Immunity 21, 387. Lutz, C. T., Glasebrook, A. L. & Fitch, F. W. (1981) Enumeration of alloreactive helper T lymphocytes which cooperate with cytolytic T lymphocytes. Eur. J. Immunol. 11, 726. Lynch, D. H., Cole, B. C, Bluestone, J. A. & Hodes, R. J. (1986) Cross-reactive recognition by antigen-specific, major histocompatibility complex-restricted T cells of a mitogen derived from Mycoplasma arthritidis is clonally expressed and I-E restricted. Eur. J. Immunol. 16, 747. Lynch, D H., Gress, R. E., Needleman, B. W., Rosenberg, S. A. & Hodes, R. J. (1985) T cell responses to Mls determinants are restricted by cross-reactive MHC determinants. J. Immunol. 134, 2071. MacDonald, H. R., Pedrazzini, T., Schneider, R., Louis, J. A., Zinkemagel, R. M. & Hengartner, H. (1988a) Intrathymic elimination of MAf-reactive (V/te4) cells during neonatal tolerance induction lo Mlsa-encoded antigens. J. Exp. Med. 167, 2005. MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C, Acha-Orbea, H., Festenstein, H., Zinkemagel, R. M. & Hengartner, H. (1988b) T cell receptor Vβ use predicts reactivity and tolerance lo MIsa-encoded antigens. Nature 332, 40. MacDonald, H. R., Hengartner, H. & Pedrazzini, T. (1988c) Intrathymic deletion of self (Misa) reactive cells prevented by neonatal anti-CD4 antibody treatment. Nature 335, 174. Macphail, S., Ishizaka, S. T., Bykowsky, M. J., Lattime, E. C. & Stutman, O. (1985) Specific neonatally induced tolerance to Mls locus determinants. J. Immunol. 156, 610. Marrack, P & Kappler, J. W. (1987) The T cell receptor. Science 238, 1073. Marrack, P. & Kappler, J. W. (1988a) T cells can distinguish between allogeneic major histocompatibility complex products on difTerent cell types. Nature 332, 840. Marrack, R & Kappler, J. W. (1988b) The T cell repertoire for antigen and MHC. Immunol. Today 9, 308. Matzinger, P. & Bevan, M. J. (1977) Why are so many T cells alloreactive Cell. Immunol. 29, I. Mentzer, S. J., Remold-O'Donnell, E., Crimins, M. A. V, Bierer, B. E., Rosen, F. S. & Burakoff, S. J. (1987) Sialophorin. a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation. J. Exp. Med. 165. 1383. Miller, R. A. & Stutman, O. (1982) Estimation of IL-2 secreting helper T cells by limiting dilution analysis, and demonstration of unexpectedly high levels of IL-2 production per responding cell. J. Immunol. 128. 2258. Molnar-Kimber, K. L. & Sprent, J. (1980) Absence of H-2 restriction in primary and secondary mixed-lymphocyte reactions to strong Mls determinants. J. Exp. Med. 151, 407. Peck, A. B., Janeway, C. A., Jr. & Wigzell, H. (1977) T lymphocyte responses to Mls locus antigens involve recognition of H-2 I region gene products. Nature 266, 840. Portoles, P., Rojo, J. M. & Janeway, C. A., Jr. (1988) Asymmetry in the recognition of antigen: self class II MHC and non-self class II MHC molecules by the same T cell receptor. J. Mot. Cell. Immunol, (in press). Reiser, R. K., Robbins, R. N., Khoe, G. P. & Bergdoll, M. S. (1983) Purification and some physiochemical properties of toxic-shock toxin. Biochemistry 22, 3907. Ryan, J. J., Mond, J. J., Finkelman, F. D. & Scher, I. (1983) Enhancement of the mixed lymphocyte reaction by in vivo treatment of stimulator spleen cells with anti-IgA antibody. J. Immunol. 130, 2534. Scblievert, P. M. (1983) Alteration of immune function by staphylococcal pyrogenic exotox-in C: Possible role in toxic-shock syndrome. J. Infect. Dis. 147, 391. Schmidt, J. J. & Spero, L. (1983) The complete amino acid sequence of staphylococcal enteroloxin Cl J. Biol. Chem. 258, 6300. Shimonkevitz, R., Kappler, J., Marrack, P. & Grey, H. (1983) Antigen recognition by H-2-restricted T cells. 1. Cell-free antigen processing. J. Exp. Med. 158, 303. Spero, L., Morlock, B. A. & Metzger, J. F. (1978) On the cross-reactivity of slaphylococcal enterotoxins A, B and C. J. Immunol. 120, 86. Sredni, B. & Schwartz, R. H. (1981) Antigen-specific, proliferating T lymphocyte clones. Methodology. specificity, MHC-restriction and alloreactivity. Immunol. REv. 54. 187. Swain, S. L. (1983) T cell subsets and the recognition of MHC class. Immunol. Rev. 74, 129. Webb, S. R., Li, J. H., MacNeil, I., Marrack, P., Sprent, J. & Wilson, D. B. (1985b) T cell receptors for responses to Mls determinals and allo-H-2 determinants appear to be encoded on different chromosomes. J. Exp. Med. 161, 269. Webb, S. R., Li, J. H., Wilson, D. B. & Sprent, J. (1985a) Capacity of small B cell-enriched populations to stimulate mixed lymphocyte reactions: Marked differences between irradiated vs. mitomycin C-treated stimulators. Eur. J. Immunol. 15, 92. Webb, S. R., Molnar-Kimber, K., Bruce, J., Sprent, J. & Wilson, D. B. (1981) T cell clones with dual specificity for Mls and various major histocompatibility complex determinants. J. Exp. Med. 154, 1970. Webb, S. R., Okamoto, A. & Sprent, J. (1988) Mls determinants and anti-Mls receptors. J. Immunogenetics 15, (in press). Webb, S. & Sprent, J. (1987) Downregulation of T cell responses by antibodies lo the T cell receptor. J. Exp. Med. 165, 584. Wieneke, A. A. (1974) Enterotoxin production by strains of Staphylococcus aureus isolated from foods and human beings. J. Exp. (Camb.) 73, 255. Wilson, D. B., Bluthe, J. L. & Nowell, P. C. (1968) Quantitative studies on the mixed lymphocyte reaction. III. Kinetics of the response. J. Exp. Med. 128, 1157. Yagi, J., Buxser, S. & Janeway, C. A., Jr. (1989) Bacterial proteins that mediate the association of a defined subset of T cell receptor: CD4 complexes with class II MHC. (Submitted for publication). Citing Literature Volume107, Issue1February 1989Pages 61-88 ReferencesRelatedInformation