On the function of neuromelanin
1996; Royal Society; Volume: 263; Issue: 1369 Linguagem: Inglês
10.1098/rspb.1996.0073
ISSN1471-2954
Autores Tópico(s)Nuclear Receptors and Signaling
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Smythies John 1996On the function of neuromelaninProc. R. Soc. Lond. B.263487–489http://doi.org/10.1098/rspb.1996.0073SectionRestricted accessArticleOn the function of neuromelanin John Smythies Google Scholar Find this author on PubMed Search for more papers by this author John Smythies Google Scholar Find this author on PubMed Published:22 April 1996https://doi.org/10.1098/rspb.1996.0073AbstractThe hypothesis is presented, based on the chemical structure of neuromelanin, that one of its functions in the catecholamine neurons in the brain is to protect the cell against toxic quinones (such as dopaminochrome and noradrenochrome, or their dihydroxy isomers) produced from the catecholamines dopamine and noradrenaline (and possibly adrenaline) during the course of prostaglandin synthesis by the enzyme prostaglandin H synthetase, or possibly by spontaneous oxidation. One aminochrome–adrenochrome–has been shown to be neurotoxic and to have psychotomimetic properties in humans. Depending on the site of production these compounds may be involved in the pathogenesis of Parkinson's disease or schizophrenia.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. Previous ArticleNext Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Wulf M, Barkovits K, Schork K, Eisenacher M, Riederer P, Gerlach M, Eggers B and Marcus K (2022) Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes, Journal of Neural Transmission, 10.1007/s00702-022-02530-4, 129:10, (1257-1270), Online publication date: 1-Oct-2022. 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