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Dual Surface‐Functionalized Janus Nanocomposites of Polystyrene/Fe 3 O 4 @SiO 2 for Simultaneous Tumor Cell Targeting and Stimulus‐Induced Drug Release

2013; Volume: 25; Issue: 25 Linguagem: Inglês

10.1002/adma.201301376

1521-4095

Feng Wang, Giovanni M. Pauletti, Juntao Wang, Jiaming Zhang, Rodney C. Ewing, Yilong Wang, Donglu Shi,

Micro and Nano Robotics

Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3O4@SiO2 and polystyrene surfaces of a unique polystyrene/Fe3O4@SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.