Design and Development of the First Peptide-Chelating Bisphosphane Bioconjugate from a Novel Functionalized Phosphorus(III) Hydride Synthon
1999; Wiley; Volume: 38; Issue: 13-14 Linguagem: Inglês
10.1002/(sici)1521-3773(19990712)38
ISSN1521-3773
AutoresHariprasad Gali, Srinivasa Karra, V. Sreenivasa Reddy, Kattesh V. Katti,
Tópico(s)Click Chemistry and Applications
ResumoRemarkable oxidative stability is shown by the carboxylate-functionalized primary bisphosphane 1. Compound 1 can be used in conjugation reactions with biomolecules for functionalization through the COOH group without prior protection of PH2 groups. A novel water-soluble bisphosphane was obtained by reaction of the PH2 groups of 1 with formaldehyde under mild conditions.
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