VERY HIGH MEASLES AND RUBELLA VIRUS ANTIBODY TITRES ASSOCIATED WITH HEPATITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, AND INFECTIOUS MONONUCLEOSIS
1974; Elsevier BV; Volume: 303; Issue: 7850 Linguagem: Inglês
10.1016/s0140-6736(74)92496-9
ISSN1474-547X
Autores Tópico(s)Cytomegalovirus and herpesvirus research
Resumo30 out of 12,269 sera which were sent to a virological laboratory to be screened against antibodies to several viruses showed very high measles or rubella antibodies although there had been no recent typical rubella or measles infection. 7 patients had chronic active hepatitis, 2 had chronic hepatitis, 6 had acute hepatitis, 4 had systemic lupus erythematosus, and 4 had infectious mononucleosis. The onset of acute hepatitis was in 2 cases associated with skin rash, whereas no other patients had skin manifestations. During the onset of acute hepatitis there occurred significant rises in the measles and/or rubella virus antibody titres in 4 cases and signs of continuous inflammation were observed in 3 cases. The findings confirm other reports that patients with chronic active hepatitis and systemic lupus erythematosus have raised titres to measles and rubella antigens. Furthermore, it seems that two other diseases, acute hepatitis and infectious mononucleosis, show in some cases very high antibody titres to measles and rubella antigens. Our data suggest that atypical viral infection plays an active role in the pathogenesis of at least some of the abovementioned conditions.
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