IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production
2015; Elsevier BV; Volume: 125; Issue: 9 Linguagem: Inglês
10.1182/blood-2014-09-600833
ISSN1528-0020
AutoresAlberto Yáñez, Madelena Y. Ng, Nargess Hassanzadeh‐Kiabi, Helen S. Goodridge,
Tópico(s)Immune Response and Inflammation
ResumoKey Points IRF8 does not instruct monocytic lineage specification in oligopotent granulocyte-monocyte progenitors. IRF8 regulates the survival and differentiation of lineage-committed progenitors to promote monocyte and suppress neutrophil production.
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