Monoclonal IgM reactive with several gangliosides in a chronic relapsing polyneuropathy
1994; Elsevier BV; Volume: 181; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(94)90570-3
ISSN1872-7972
AutoresIsabelle Brindel, Jean‐Louis Preud'homme, Jean‐Michel Vallat, Didier Vincent, Jean-Luc Vasquez, Marie‐Odile Jauberteau,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoA possibly pathogenic serum monoclonal IgMλ from a patient with chronic relapsing polyneuropathy was shown to react with the disialosyl-lactosyl residue (NeuAcα2–8NeuAcα2–3)-Ga1β1-4Glc expressed by GD1b, GT1b, GQ1b, GD2 and GD3. A part of this epitope in terminal position in GM3, GD1a and LM1 was also recognized by the IgMλ.
Referência(s)