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BIBTEX RIS

Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT 2 SL 1027 by N -fumarylcarboxyamido-L-2,3-diaminopropionic acid

1984; Elsevier BV; Volume: 120; Issue: 3 Linguagem: Inglês

10.1016/s0006-291x(84)80187-4

ISSN

1090-2104

Autores

Henryk Chmara, Ryszard Andruszkiewicz, E. Borowski,

Tópico(s)

Enzyme function and inhibition

Resumo

N beta- fumarylcarboxyamido -L-2,3-diaminopropionic acid ( FCDP ), a novel glutamine analog, inhibits the reaction of glucosamine-6-phosphate synthetase (EC 5.3.1.19) from Salmonella typhimurium LT 2 by irreversible inactivation of the enzyme. The kinetic data on enzyme inhibition and inactivation are presented. It is suggested that the enzyme inactivation occurs according to a sequential mechanism.

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