ATM Breaks into Heterochromatin
2008; Elsevier BV; Volume: 31; Issue: 3 Linguagem: Inglês
10.1016/j.molcel.2008.07.004
ISSN1097-4164
AutoresÓscar Fernández-Capetillo, André Nussenzweig,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoHeterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al., 2008Goodarzi A.A. Noon A.T. Deckbar D. Ziv Y. Shiloh Y. Löbrich M. Jeggo P.A. Mol. Cell. 2008; 31: 167-177Abstract Full Text Full Text PDF PubMed Scopus (649) Google Scholar reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility.
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