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Long term complete remission of severe nephrotic syndrome secondary to diffuse global (IV-G) lupus nephritis following autologous, haematopoietic peripheral stem (CD34+) cell transplantation

2006; SAGE Publishing; Volume: 15; Issue: 1 Linguagem: Inglês

10.1191/0961203306lu2241cr

1477-0962

A Marmont, Francesca Gualandi, Maria Teresa Van Lint, Carlo Guastoni, Andrea Bacigalupo,

T-cell and B-cell Immunology

Autologous haematopoietic stem cell transplantation has become an accepted powerful therapeutic procedure for patients with severe, intractable SLE. Here we describe a 26-year old patient with stage IV-G diffuse global proliferative lupus nephritis and refractory nephrotic syndrome who responded to autologous peripheral stem cell transplantation (ASCT) after two mobilization procedures. Five years later the patient is in complete clinical and immunologic remission. The indications for ASCT and its mechanism of action are briefly discussed.