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Destruxin-A4 Chlorohydrin, a Novel Destruxin from Fungus OS-F68576: Isolation, Structure Determination, and Biological Activity as an Inducer of Erythropoietin

1998; American Chemical Society; Volume: 61; Issue: 2 Linguagem: Inglês

10.1021/np970475c

1520-6025

Ping Cai, David F. Smith, Barry Katz, Cedric J. Pearce, Debra A. Venables, David R. Houck,

Microbial Natural Products and Biosynthesis

In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 microM.