Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance
1995; Lippincott Williams & Wilkins; Volume: 45; Issue: 12_suppl_8 Linguagem: Inglês
10.1212/wnl.45.12_suppl_8.s66
ISSN1526-632X
AutoresKathryn Elliott, Marina Brodsky, A. Hynansky, Kathleen M. Foley, Charles E. Inturrisi,
Tópico(s)Pharmacological Receptor Mechanisms and Effects
ResumoThe oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in zoster-associated neuralgia.
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