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Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae

2014; Multidisciplinary Digital Publishing Institute; Volume: 3; Issue: 3 Linguagem: Inglês

10.3390/pathogens3030743

2076-0817

Claudia Vuotto, Francesca Longo, Maria Pia Balice, Gianfranco Donelli, Pietro E. Varaldo,

Urinary Tract Infections Management

The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae.