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Stereocontrolled synthesis of α,β-unsaturated carboxylic esters from O-methyl-C,O-bis(trimethylsilyl)ketene acetal and aliphatic aldehydes

1981; Elsevier BV; Volume: 22; Issue: 19 Linguagem: Inglês

10.1016/s0040-4039(01)90445-9

1873-3581

Isamu Matsuda, Yusuke lzumi,

Organic Chemistry Synthesis Methods

(R*,S*) Selective aldol type reaction of O-methyl-C,O-bis(trimethylsilyl)ketene acetal (1) with aldehydes and stereoselective formation of α,β-unsaturated carboxylic esters are attained by the combination of Z-1 and Lewis acids.