Protein Lysine Acylation and Cysteine Succination by Intermediates of Energy Metabolism
2012; American Chemical Society; Volume: 7; Issue: 6 Linguagem: Inglês
10.1021/cb3001793
ISSN1554-8937
AutoresHening Lin, Xiaoyang Su, Bin He,
Tópico(s)Autophagy in Disease and Therapy
ResumoIn the past few years, several new protein post-translational modifications that use intermediates in metabolism have been discovered. These include various acyl lysine modifications (formylation, propionylation, butyrylation, crotonylation, malonylation, succinylation, myristoylation) and cysteine succination. Here, we review the discovery and the current understanding of these modifications. Several of these modifications are regulated by the deacylases, sirtuins, which use nicotinamide adenine dinucleotide (NAD), an important metabolic small molecule. Interestingly, several of these modifications in turn regulate the activity of metabolic enzymes. These new modifications reveal interesting connections between metabolism and protein post-translational modifications and raise many questions for future investigations.
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