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MLL-AF4 Gene Fusions in Normal Newborns

1999; Elsevier BV; Volume: 93; Issue: 3 Linguagem: Inglês

10.1182/blood.v93.3.1107

1528-0020

M.-H. Kim-Rouille, Angus MacGregor, Leanne M. Wiedemann, Mel Greaves, Cristina Navarrete,

Acute Myeloid Leukemia Research

To the Editor: Uckun et al[1][1] have reported that bona fide in-frame fusion MLL-AF4 fusion sequences are detectable, using a sensitive nested reverse transcription-polymerase chain reaction (RT-PCR) method, in around 25% of normal fetal bone marrow and liver samples and in 1 of 6 infant bone