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BIBTEX RIS

Factors associated with low bone mineral density in a Brazilian cohort of vertically HIV-infected adolescents

2012; Elsevier BV; Volume: 16; Issue: 12 Linguagem: Inglês

10.1016/j.ijid.2012.07.019

1878-3511

Annie Schtscherbyna, Maria Fernanda Miguens Castelar Pinheiro, Laura Maria Carvalho de Mendonça, Carla Maria Barroso Gouveia, Ronir Raggio Luiz, Elizabeth S. Machado, Maria Lúcia Fleiuss Farias,

Vitamin D Research Studies

To assess the prevalence and factors associated with low bone mineral density (BMD) in HIV-infected adolescents.This was a cross-sectional study of a Brazilian cohort of vertically HIV-infected adolescents. Body composition and lumbar spine (LS) and total body (TB) BMD were estimated by dual-energy X-ray absorptiometry (DXA). Low BMD was considered for a Z-score ≤-2 standard deviations. Pubertal development, anthropometric data, laboratory measurements, antiretroviral regimen, and time of immunological and virological recovery were evaluated as factors associated with a low BMD.Seventy-four adolescents aged 17.3 ± 1.8 years were studied. Low BMD was present in 32.4% of them. LS and TB BMD Z-scores were positively correlated with weight, body mass index (BMI), BMI Z-score, total body fat, and nutritional status. Patients on tenofovir had lower LS and TB BMD Z-scores. Time on tenofovir was indirectly correlated with LS and TB BMD Z-scores. No difference was found regarding levels of calcium, parathyroid hormone, or 25-hydroxyvitamin D according to BMD status.Control of the HIV infection, especially before the initiation of puberty, might have a positive influence on bone gain. Body composition and nutritional status had a positive influence on BMD that was more evident in females, suggesting that nutritional intervention may have a positive impact on BMD.