On the nature of “Maculotoxin”, a toxin from the blue-ringed octopus (Hapalochlaena maculosa)
1976; Elsevier BV; Volume: 14; Issue: 6 Linguagem: Inglês
10.1016/0041-0101(76)90057-x
ISSN1879-3150
AutoresH.D. Crone, Bruce W. Leake, M.W. Jarvis, Shirley E. Freeman,
Tópico(s)Chemical synthesis and alkaloids
ResumoTwo lethal fractions were prepared from the posterior salivary glands of Hapalochlaena maculosa by methanol extraction and chromatography on a silica gel column. These two fractions were compared with the lethal water extract of the glands, previously named maculotoxin (MTX), by thin layer and ion exclusion chromatography. It was concluded that the two methanol fractions contained the same active principle, that this was the same material as MTX, and that it closely resembled tetrodotoxin. No evidence for the existence of a second toxin in effective amounts was found.
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