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BIBTEX RIS

Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment

2012; Bentham Science Publishers; Volume: 7; Issue: 4 Linguagem: Inglês

10.2174/157340311799960645

ISSN

1875-6557

Autores

М. И. Волкова, Raymond R. Russell,

Tópico(s)

Electron Spin Resonance Studies

Resumo

Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition. Keywords: Left ventricular dysfunction, doxorubicin, oxidant stress.

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