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Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

2012; Elsevier BV; Volume: 84; Linguagem: Inglês

10.1016/j.phytochem.2012.07.023

1873-3700

Pierre‐Marie Allard, Pieter Leyssen, Marie‐Thérèse Martin, Mélanie Bourjot, Vincent Dumontet, Cécilia Eydoux, Jean‐Claude Guillemot, Bruno Canard, Cyril Poullain, Françoise Guéritte, Marc Litaudon,

Hymenoptera taxonomy and phylogeny

The chemical study of the bark and the wood of Trigonostemon cherrieri, a rare endemic plant of New Caledonia, led to the isolation of a series of highly oxygenated daphnane diterpenoid orthoesters (DDO) bearing an uncommon chlorinated moiety: trigocherrins A–F and trigocherriolides A–D. Herein, we describe the isolation and structure elucidation of the DDO (trigocherrins B–F and trigocherriolides A–D). We also report the antiviral activity of trigocherrins A, B and F (1, 2 and 6) and trigocherriolides A, B and C (7–9) against various emerging pathogens: chikungunya virus (CHIKV), Sindbis virus (SINV), Semliki forest virus (SFV) and dengue virus (DENV).