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135 CLINICAL SIGNIFICANCE OF CXCL16/CXCR6 EXPRESSION IN PATIENTS WITH PROSTATE CANCER

2011; Lippincott Williams & Wilkins; Volume: 185; Issue: 4S Linguagem: Inglês

10.1016/j.juro.2011.02.202

1527-3792

Hyeon Woo Kim, Hong Koo Ha, Wan Lee, Eun Park, Dong Gil Shin, Jeong Zoo Lee, Moon Kee Chung,

Immunotherapy and Immune Responses

You have accessJournal of UrologyProstate Cancer: Basic Research1 Apr 2011135 CLINICAL SIGNIFICANCE OF CXCL16/CXCR6 EXPRESSION IN PATIENTS WITH PROSTATE CANCER Hyeon Woo Kim, Hong Koo Ha, Wan Lee, Eun Park, Dong Gil Shin, Jeong Zoo Lee, and Moon Kee Chung Hyeon Woo KimHyeon Woo Kim Busan, Korea, Republic of More articles by this author , Hong Koo HaHong Koo Ha Busan, Korea, Republic of More articles by this author , Wan LeeWan Lee Busan, Korea, Republic of More articles by this author , Eun ParkEun Park Busan, Korea, Republic of More articles by this author , Dong Gil ShinDong Gil Shin Busan, Korea, Republic of More articles by this author , Jeong Zoo LeeJeong Zoo Lee Busan, Korea, Republic of More articles by this author , and Moon Kee ChungMoon Kee Chung Busan, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.202AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We hypothesized that the CXCL16-CXCR6 ligand-receptor system may play an important role in prostate cancer progression. METHODS Levels of CXCL16 and CXCR6 expression were evaluated in prostate cancer cell lines (PC-3 and LNCaP) and in normal prostate epithelial cells (PrEC) as well as tissues from 354 patients. RESULTS The immunohistochemical expression of CXCL16/CXCR6 was greater in PC-3/LNCaP than in PrEC. The expression of CXCL16/CXCR6 was significantly higher in prostate cancer than benign prostatic hypertrophy. Using RT-PCR, the expression of CXCL16/CXCR6 was greater in PC-3/LNCaP than in PrEC. CXCL16/CXCR6 was weakly detected in lung and liver tissue, whereas CXCL16 was highly expressed in bone metastases. CXCL16 immunostaining was related to the Gleason score, T stage, tumor volume, perineural invasion, and lymph node metastasis. However, biochemical PSA recurrence was not related to the expression of CXCL16/CXCR6. CONCLUSIONS High CXCL16/CXCR6 expression may be related to aggressive cancer behavior and high CXCL16 expression in bone metastases. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e57 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hyeon Woo Kim Busan, Korea, Republic of More articles by this author Hong Koo Ha Busan, Korea, Republic of More articles by this author Wan Lee Busan, Korea, Republic of More articles by this author Eun Park Busan, Korea, Republic of More articles by this author Dong Gil Shin Busan, Korea, Republic of More articles by this author Jeong Zoo Lee Busan, Korea, Republic of More articles by this author Moon Kee Chung Busan, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...