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Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica

2000; Q16635223; Volume: 128; Issue: 1 Linguagem: Inglês

10.4067/s0034-98872000000100004

0717-6163

María Teresa Ulloa F, María Soledad Giglio M, Lorena Porte, Adriana Santa Cruz A, Paul McNab M, Alberto Fica C, María Eugenia Pinto C, Keyko Kawaguchi G, Alejandra Carmi K,

Inflammasome and immune disorders

The virulence of Streptococcus pyogenes is determined by a variety of structural molecules, toxins and complex enzymes. Pyrogenic exotoxins cause fever, erythematous reactions, cytotoxic and immunological effects.To assess the frequency of speA, SpeB and SpeC genes in Chilean Streptococcus pyogenes strains and their association with the invasiveness of infections.The genes for pyrogenic exotoxins SpeA, SpeB and SpeC were determined by polymerase chain reactions in 114 strains of group A Streptococcus pyogenes isolated from Chilean patients with invasive or non invasive infections.The gene for SpeA was present in 30.7% of isolates, the gene for SpeB was present in 69.3% and the gen for SpeC in 44.7% of isolates. The gene for SpeA was present in 20 of 33 invasive infections and in 15 of 81 non invasive infections (p < 0.0001). On the contrary, the gene for SpeC was present in 11 of 33 invasive infections and in 41 of 81 non invasive infections (p < 0.05). The frequency of speB was similar in invasive and non invasive infections.There is a clear relationship between the presence of SpeA genes and the severity of infections caused by Streptococcus pyogenes.