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Separate and Combined Effects of Timolol Maleate and Acetazolamide in Open-Angle Glaucoma

1981; Elsevier BV; Volume: 92; Issue: 6 Linguagem: Inglês

10.1016/s0002-9394(14)75631-4

1879-1891

Frank G. Berson, David L. Epstein,

Cerebral Venous Sinus Thrombosis

We compared the intraocular pressure-decreasing effect of timolol maleate alone, acetazolamide alone, and combined timolol and acetazolamide therapy in nine patients with bilateral chronic open-angle glaucoma. Timolol decreased intraocular pressure at least as effectively as acetazolamide. The two medications together were more effective than either medication alone, but they did not have a fully additive effect. Episcleral venous pressures and outflow facilities did not vary significantly with any of the three treatment regimens. We compared the intraocular pressure-decreasing effect of timolol maleate alone, acetazolamide alone, and combined timolol and acetazolamide therapy in nine patients with bilateral chronic open-angle glaucoma. Timolol decreased intraocular pressure at least as effectively as acetazolamide. The two medications together were more effective than either medication alone, but they did not have a fully additive effect. Episcleral venous pressures and outflow facilities did not vary significantly with any of the three treatment regimens.