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Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands

2010; Elsevier BV; Volume: 105; Issue: 3 Linguagem: Inglês

10.1016/j.jinorgbio.2010.12.002

1873-3344

Mauro Ravera, Elisabetta Gabano, Manuele Sardi, Giuseppe Ermondi, Giulia Caron, Michael J. McGlinchey, Helge Müller‐Bunz, Elena Monti, Marzia Bruna Gariboldi, Domenico Osella,

Lanthanide and Transition Metal Complexes

The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis(imidazole) derivatives – the so-called Joseph ligands – are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity.