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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Waiting time to radiotherapy as a prognostic factor for glioblastoma patients in a scenario of medical disparities

2015; Thieme Medical Publishers (Germany); Volume: 73; Issue: 2 Linguagem: Inglês

10.1590/0004-282x20140202

ISSN

1678-4227

Autores

Luiz Victor Maia Loureiro, Lucíola de Barros Pontes, Donato Callegaro‐Filho, Lía Raquel Oliveira, Eduardo Weltman, Elivane da Silva Victor, Adrialdo José Santos, Lia Raquel Rodrigues Borges, Roberto Araújo Segreto, Suzana Mária Fleury Malheiros,

Tópico(s)

Meningioma and schwannoma management

Resumo

Objective To evaluate the effect of waiting time (WT) to radiotherapy (RT) on overall survival (OS) of glioblastoma (GBM) patients as a reliable prognostic variable in Brazil, a scenario of medical disparities. Method Retrospective study of 115 GBM patients from two different health-care institutions (one public and one private) in Brazil who underwent post-operative RT. Results Median WT to RT was 6 weeks (range, 1.3-17.6). The median OS for WT ≤ 6 weeks was 13.5 months (95%CI , 9.1-17.9) and for WT > 6 weeks was 14.2 months (95%CI, 11.2-17.2) (HR 1.165, 95%CI 0.770-1.762; p = 0.470). In the multivariate analysis, the variables associated with survival were KPS (p < 0.001), extent of resection (p = 0.009) and the adjuvant treatment (p = 0.001). The KPS interacted with WT to RT (HR 0.128, 95%CI 0.034-0.476; p = 0.002), showing that the benefit of KPS on OS depends on the WT to RT. Conclusion No prognostic impact of WT to RT could be detected on the OS. Although there are no data to ensure that delays to RT are tolerable, we may reassure patients that the time-length to initiate treatment does not seem to influence the control of the disease, particularly in face of other prognostic factors.

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