Portal de Periódicos da CAPES

B cell activation, tolerance and antigen-presenting function

1995; Elsevier BV; Volume: 7; Issue: 1 Linguagem: Inglês

10.1016/0952-7915(95)80037-9

1879-0372

Philip D. Hodgkin, Antony Basten,

Immunotherapy and Immune Responses

Recent advances in the understanding of the collaboration between T cells and B cells have provided a novel framework within which to analyse the mechanisms of B-cell tolerance and its breakdown. Of particular interest has been the finding that B cell anergy is due to defective antigen receptor mediated functions, while the antigen-processing machinery and CD40-dependent activation pathways are unaffected. Thus, the anergic B cell, which otherwise has a short lifespan, can be rescued by a number of regimes to participate in autoimmune responses.