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The Pathogenesis of Myelofibrosis in Myeloproliferative Disorders

1980; American College of Physicians; Volume: 92; Issue: 6 Linguagem: Inglês

10.7326/0003-4819-92-6-857

1539-3704

Jerome E. Groopman,

Acute Myeloid Leukemia Research

Editorial Notes1 June 1980The Pathogenesis of Myelofibrosis in Myeloproliferative DisordersJEROME E. GROOPMAN, M.D.JEROME E. GROOPMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pathogenesis of bone marrow fibrosis in the myeloproliferative disorders is unknown. Various other conditions, benign and malignant, that involve the marrow, including osteopetrosis, Paget's disease, thorium dioxide administration, hairy cell leukemia, and carcinoma of the breast, may also be associated with marked myelofibrosis. The bone marrow scarring in such diverse disorders probably arises via different mechanisms. My comments here focus on the genesis of marrow fibroblast proliferation in myeloproliferative disorders.Fibroblasts are the source of the silver-staining precollagen termed reticulin that replaces normal marrow stroma in disorders with myelofibrosis. Although the bone marrow fibroblast was once believed to be...References1. GOLDEHOCKINGQUANSPARKESGALE DWSRR. Origin of human bone marrow fibroblasts. Br J Haematol. 1980;44:183-7. CrossrefMedlineGoogle Scholar2. FRIEDENSTEINIVANOV-SMOLENSKICHAJLAKJAN AAR. Origin of bone marrow stromal mechanocytes in radiochimeras and heterotopic transplants. Exp Hematol. 1978;6:440-4. MedlineGoogle Scholar3. VAN SLYCKWEISSDULLY ELM. Chromosomal evidence for the secondary role of fibroblastic proliferation in acute myelofibrosis. Blood. 1970;36:729-35. CrossrefMedlineGoogle Scholar4. JACOBSONSALOFIALKOW RAP. Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood. 1978;51:189-94. 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Malignant myelosclerosis. Br Med J. 1963;2:472-7. CrossrefMedlineGoogle Scholar17. ROJERMULDERNIEWEG RNH. "Classic" and "acute" myelofibrosis. Acta Haematol. 1978;60:108-16. CrossrefMedlineGoogle Scholar18. BEARMANPANGALISRAPPAPORT RGH. Acute ("malignant") myelosclerosis. Cancer. 1979;43:279-93. CrossrefMedlineGoogle Scholar19. DEN OTTOLANDERTE VELDEBREDEROO GJP. Megakaryoblastic leukemia (acute myelofibrosis): a report of three cases. Br J Haematol. 1979;42:9-20. CrossrefMedlineGoogle Scholar20. ANTONIADESSCHERSTILES HCC. Purification of human platelet-derived growth factor. Proc Natl Acad Sci USA. 1979;76:1809-13. CrossrefMedlineGoogle Scholar21. BURKEROSS JR. Collagen synthesis by monkey arterial smooth muscle cells during proliferation and quiescence in culture. Exp Cell Res. 1977;107:387-95. CrossrefMedlineGoogle Scholar22. PARETIMANNUCCIASTIGUARINIGULIOTTATURA FPDALS. Acquired storage pool disease in myeloproliferative disorders. Blood. 1978;52(suppl):286. Abstract. Google Scholar23. RAPPEPORTPARKMANBELLILEVEYROSENNATHAN JRJRFD. Reversibility of myelofibrosis after bone marrow transplantation. Blood. 1978;52(suppl):589. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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