Portal de Periódicos da CAPES

Controlled Trial of D-Penicillamine in Rheumatoid Arthritis: Dose Effect and the Role of Zinc

1976; Taylor & Francis; Volume: 5; Issue: 4 Linguagem: Inglês

10.3109/03009747609099913

1502-7732

C Méry, F Delrieu, R Ghozlan, L Saporta, F Simon, B Amor, C J Menkès, F Delbarre,

Trace Elements in Health

The findings are reported of a controlled clinical trial comparing in 66 rheumatoid arthritis patients 0 g (placebo), and 0.50 g a day and 1 g a day of penicillamine. Each of these groups has been subdivided into two, one part receiving 5 mg a day of zinc metal supplement, the other a placebo. The trial was planned to be double-blind, and for each patient to take part for 4 months. The results prove the effectiveness of penicillamine in rheumatoid arthritis. 0.50 g a day has the same effect as 1 g a day but gives less side effects. Zinc supplement inhibits the clinical effects of penicillamine but does not prevent the side effects.