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Genetic profile of the transcriptional signals from the adenovirus major late promoter

1988; Elsevier BV; Volume: 165; Issue: 1 Linguagem: Inglês

10.1016/0042-6822(88)90657-5

1096-0341

Richard F. Lee, Michael F. Concino, Roberto Weinmann,

RNA Research and Splicing

Identical functional profiles were obtained for in vivo and in vitro transcription assays of more than 30 site-directed point mutants within the adenovirus major late promoter. The functional limits of the functional regions encompassing upstream promoter element are defined (-51 to -61), as well as a region around the transcription start site (-1 to +1), flanked by regions insensitive to sequence alterations.