Demonstration of an activation regulated NF-κB/I-κBα complex in human platelets
2002; Elsevier BV; Volume: 106; Issue: 4-5 Linguagem: Inglês
10.1016/s0049-3848(02)00130-5
ISSN1879-2472
AutoresFengqi Liu, Steve Morris, Jerry L. Epps, Roger C. Carroll,
Tópico(s)Platelet Disorders and Treatments
ResumoIn eukaryotic cells, the ubiquity of the signaling system of transcription factor nuclear factor-kappa B (NF-kappaB)/I-kappa B (I-kappaB) is undisputed. Numerous studies have reported that the NF-kappaB/I-kappaB complex plays a pivotal role in regulating gene expression controlling cell differentiation, cell proliferation, inflammation, oncogenesis, and apoptosis. Here we show that NF-kappaB/I-kappaB families exist in human platelets, natural anuclear corpuscles derived from megakaryocytes. Moreover, the I-kappaB kinase (IKK) is present and may phosphorylate I-kappaB during platelet activation. Coupled with intracellular calcium flux, this leads to I-kappaB dissociation from the NF-kappaB/I-kappaB complex and proteolysis. The NF-kappaB/I-kappaB proteins may have function independent of gene regulation in platelets.
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