IN VITRO STUDIES OF CEPHANONE, A 3-HETEROCYCLIC-THIOMETHYL CEPHALOSPORIN DERIVATIVE
1973; Springer Nature; Volume: 26; Issue: 3 Linguagem: Inglês
10.7164/antibiotics.26.153
ISSN1881-1469
AutoresHarold C. Neu, Elaine B. Winshell,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoThe antibacterial spectrum of cephanone, a 3-heterocyclic thiomethyl cephalosporin derivative, is similar to that of cephalothin and cephalexin. Cephanone is less active against gram-positive organisms but is more active against Escherichia coli than cephalothin. Activity against Klebsiella, Proteus mirabilis and Salmonella is similar to cephalothin. Some Enterobacter strains are ?? susceptible to 8 μg/ml or less. Cephanone is relatively resistant to hydrolysis by gram-negative beta-lactamases. It is not a competitive inhibitor of the hydrolysis of penicillins by beta-lactamases.
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