Portal de Periódicos da CAPES

Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis

2004; Oxford University Press; Volume: 41; Issue: 2 Linguagem: Inglês

10.1016/j.femsim.2004.02.004

1574-695X

Jemima Stockton, Joanna M. M. Howson, Agnes A. Awomoyi, Keith McAdam, Jenefer M. Blackwell, Melanie J. Newport,

Mycobacterium research and diagnosis

The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.