Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine
1971; Wiley; Volume: 43; Issue: 3 Linguagem: Inglês
10.1111/j.1476-5381.1971.tb07181.x
ISSN1476-5381
Autores Tópico(s)Memory and Neural Mechanisms
ResumoSummary Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25–30% after 30 minutes. The effect of several receptor blocking drugs on the amphetamine‐induced cerebral glycogenolysis was studied. dl ‐Propranolol (0·25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine‐induced glycogenolysis. d ‐Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses. It is concluded that amphetamine‐induced glycogenolysis in the mouse brain may be mediated through a β‐adrenoceptor.
Referência(s)