F1-ATPase Is a Highly Efficient Molecular Motor that Rotates with Discrete 120° Steps
1998; Cell Press; Volume: 93; Issue: 7 Linguagem: Inglês
10.1016/s0092-8674(00)81456-7
ISSN1097-4172
AutoresRyohei Yasuda, Hiroyuki Noji, Kazuhiko Kinosita, Masasuke Yoshida,
Tópico(s)Advanced NMR Techniques and Applications
ResumoA single molecule of F1-ATPase, a portion of ATP synthase, is by itself a rotary motor in which a central γ subunit rotates against a surrounding cylinder made of α3β3 subunits. Driven by three catalytic βs, each fueled with ATP, γ makes discrete 120° steps, occasionally stepping backward. The work done in each step is constant over a broad range of imposed load and is close to the free energy of hydrolysis of one ATP molecule.
Referência(s)