Determination of sulfanilic acid in the presence of sulfanilamide and some sulfa drugs by reversed-phase ion-pair high-performance liquid chromatography
1980; Elsevier BV; Volume: 196; Issue: 3 Linguagem: Inglês
10.1016/s0021-9673(00)84754-8
ISSN1873-3778
AutoresRobert C Doerr, N. Parris, O.W. Parks,
Tópico(s)Pesticide Residue Analysis and Safety
ResumoSulfathiazole is a short-acting sulfonamide. It is also called “norsulfazolum,” “sulfanilamidothiazolum,” “sulphathiatole,” “sulfona–zolum,” and “solfatiazolo.” Sulfathiazole is a white or almost white, crystalline powder, which is odorless or almost odorless. The sodium salt is a white or yellowish-white microcrystalline powder. The solubility of sulfathiazole is determined in mixtures of dimethylacetamide glycerol and water, and the solubility profiles are reproduced by the use of extended Hildebrand solubility approach. The solution rate and solubility of an aqueous sulfathiazole suspension are discussed in this chapter. The polymorphism of sulfathiazole has been investigated by numerous workers. The 13C nuclear magnetic resonance (NMR) spectrum of sulfathiazole has been determined in deuteriodimethyl sulfoxide at 25.15 MHz employing the pulse Fourier transform technique. The Raman spectra of the various forms of sulfathiazole have been measured on a Spex triple monochromator spectrophotometer using a krypton ion laser at a wavelength of 647 nm.
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