Effects of antacid or ascorbic acid on tissue accumulation and urinary excretion of 51chromium
1990; Elsevier BV; Volume: 10; Issue: 12 Linguagem: Inglês
10.1016/s0271-5317(05)80132-0
ISSN1879-0739
AutoresCarol D. Seaborn, Barbara J. Stoecker,
Tópico(s)Heavy Metal Exposure and Toxicity
ResumoAbsorption of trivalent chromium is low. Unbound chromium can form insoluble complexes in the gastrointestinal tract. In this study, effects of a calcium-based antacid or ascorbic acid on 51chromium from chromium chloride were investigated. Rats were dosed with 1 mL of test substance (containing 150 mg calcium carbonate or 10 mg ascorbic acid) or 1 mL water followed by 20 uCi 51chromium chloride. Twenty-four hours after dosing, 51chromium in cumulative urine was higher (p<0.02) in the group dosed with ascorbic acid than in the groups dosed with antacid or water. Accumulation of 51chromium in the kidney, testes, and spleen was lower (p<0.05) in rats dosed with antacid than in those dosed with ascorbic acid or water. These data confirm that absorption of chromium chloride is low and suggest that antacids have a negative effect on chromium absorption from chromium chloride.
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