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Synthesis of New Molecules Adopting a Unique Sigmoid Conformation with Stacked Aromatic Rings in the Crystalline State

1993; Elsevier BV; Volume: 36; Issue: 8 Linguagem: Inglês

10.3987/com-93-6389

1881-0942

Yoshimitsu Nagao, Shigeki Sano, Satoshi Nakagawa, Masanobu Suzuki, Motoo Shiro, Masaru Kido, Takao Nishi,

Chemistry and Chemical Engineering

Synthesis of new molecules adopting a unique sigmoid conformation in the crystalline state has been achieved.Conformational analysis of these 1 molecules is investigated by utilizing X-ray and H nmr analyses.In the modem science of molecular recognition, exploitation of new molecular devices and functional molecules 1 may be of considerable current interest.Therefore, there have been many reports on the unique molecule involving molecular c ~e f t s , ~ molecular t ~e e z e r s , ~ and receptor models4 for drug and biologically important substances.In the design of these molecules, a folded or a macrocyclic suuctural mode seems to be adopted most likely in order to gain a high degree of specificity between the host molecule and the guest molecule.'-5Even in the field of drug creation, adoption of a folded conformation in the molecule would be one of novel promising approaches because enzymes, proteins, nucleic acids, and other polar macro molecules never display any stretched molecular aspect.6Recently, we established a general preparation method for the compounds adopting a folded conformation (A in Figure I) with stacked aromatic rings, especially heterocyclic and carbocyclic aromatic moieties?Bridging