Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma
1991; American Association of Neurological Surgeons; Volume: 74; Issue: 6 Linguagem: Inglês
10.3171/jns.1991.74.6.0905
ISSN1933-0693
AutoresJeffrey Krischer, Abdelsalem H. Ragab, Larry E. Kun, Tae Hyong Kim, John P. Laurent, James M. Boyett, Cornelius J. Cornell, Michael P. Link, A Lüthy, Bruce M. Camitta,
Tópico(s)Ocular Oncology and Treatments
Resumo✓ In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age. Patients treated with irradiation plus MOPP had a statistically significant increase in overall survival rate at 5 years posttreatment compared to patients treated with radiation therapy alone (74% vs. 56%; p = 0.06, adjusted for race and gender). Although the overall study failed to show a statistically significant advantage for irradiation plus MOPP in event-free survival (p = 0.18), statistical significance was attained in children 5 years of age or older (p = 0.05). More severe hematological toxicities occurred in the group with irradiation plus MOPP; however, this hematotoxicity appeared to be tolerable and acceptable. These results suggest that patients may benefit from combined irradiation and chemotherapy following surgery for medulloblastoma.
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