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Oroidin Inhibits the Activity of the Multidrug Resistance Target Pdr5p from Yeast Plasma Membranes

2011; American Chemical Society; Volume: 74; Issue: 2 Linguagem: Inglês

10.1021/np1006247

1520-6025

Fernanda R. da Silva, Ana Claudia Tessis, Patricia F. Ferreira, Luciana P. Rangel, Aline S. Garcia-Gomes, Fábio Renato Pereira, Roberto G. S. Berlinck, Guilherme Ramos da Silva Muricy, Antônio Ferreira‐Pereira,

Cancer therapeutics and mechanisms

Oroidin was isolated from the marine sponge Agelassventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.