Portal de Periódicos da CAPES

Association of MICA and MICB alleles with symptomatic dengue infection

2011; Elsevier BV; Volume: 72; Issue: 10 Linguagem: Inglês

10.1016/j.humimm.2011.06.010

1879-1166

Gissel Garcı́a, Florencia del Puerto, Ana Beatriz Alvarez Pérez, Beatríz Sierra, Eglys Aguirre, Mihoko Kikuchi, Lizet Sánchez, Kenji Hirayama, María G. Guzmán,

Viral Infections and Vectors

Dengue viruses (DV) are one of the most important arthropod-borne viral diseases in the developing world. DV can cause syndromes that are either self-limiting or severe. Allelic variants of human leukocyte antigen (HLA) genes have been demonstrated to be associated with disease susceptibility. Here we report the association of nonclassical HLA class I MICA–MICB genes with disease outcome during DV infection. A sequencing-based typing method and genotyping of MICA and MICB in a well-characterized group of Cuban individuals with dengue hemorrhagic fever (DHF), dengue fever (DF), or asymptomatic dengue infection (ADI) was performed. Statistical analysis revealed a tendency for MICA*008 and MICB*008 to associate with susceptibility to illness when symptomatic versus asymptomatic cases (odds ratio [OR] = 2.1, pv = 0.03, and OR = 10.4, p = 0.0096, respectively) were compared. Surprisingly, a stronger association of both allelic forms was observed for the DF patients compared with the ADI group (MICA*008, OR = 5.2, p = 0.0001; and MICB*008, OR = 13.2, p = 0.0025) rather than the severe cases. Major histocompatibility class I-related gene-related natural killer cells and/or γδ and αβ T-cell activation might regulate the development of symptomatic DF and DHF.