Portal de Periódicos da CAPES

Immunisations in solid-organ transplant recipients

2002; Elsevier BV; Volume: 359; Issue: 9310 Linguagem: Inglês

10.1016/s0140-6736(02)08028-5

1474-547X

Klaus Stark, Matthias Günther, Christian Schönfeld, Stefan G. Tullius, Ulrich Bienzle,

Cytomegalovirus and herpesvirus research

Solid-organ transplant recipients are at increased risk of various infectious diseases, some of which are vaccine preventable. Immunisations are among the most efficient interventions available. Solid-organ tranplant recipients would greatly benefit from effective immunisations, provided the recommendations are based on a careful risk-benefit analysis in which the effectiveness of the vaccine is weighed against possible adverse reactions, including graft rejection. In this review, we summarise the data from studies on relevant immunisations in solid-organ transplant recipients. The major issues are the immunogenicity and safety of immunisations, the factors associated with poor immune response, and recommendations for immunisation schemes.