Portal de Periódicos da CAPES

Facile preparation of chloromethylaryl solid supports using methanesulfonyl chloride and Hunig's base

1997; Elsevier BV; Volume: 38; Issue: 33 Linguagem: Inglês

10.1016/s0040-4039(97)01029-0

1873-3581

David A. Nugiel, Dean A. Wacker, Gregory A. Nemeth,

Asymmetric Synthesis and Catalysis

Several commercially available hydroxymethylaryl resins were converted to their corresponding chloromethyl analogs by simple treatment with methanesulfonyl chloride and Hunig's base in DMF at 25 °C over 3 days. This mild method gave quantitative conversions as determined by elemental analysis and 13C NMR.