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Efficacy of Two Regimens of Misoprostol for Early Second-Trimester Pregnancy Termination

2005; Karger Publishers; Volume: 20; Issue: 6 Linguagem: Inglês

10.1159/000088048

1421-9964

Cristina Guix, Montse Palacio, F. Figueras, M. Bennásar, L. Zamora, Oriol Coll, V. Cararach,

Prenatal Substance Exposure Effects

<i>Objective:</i> To compare the efficacy of a combined regimen of misoprostol with vaginal misoprostol for early 2nd-trimester pregnancy termination. <i>Methods:</i> This is a prospective study that includes 79 pregnant women who requested legal termination of 2nd-trimester pregnancy between 13 and 22 weeks. Two regimens of misoprostol were used. Group 1: 400 µg of oral plus 400 µg vaginal misoprostol every 8 h (combined regimen) and group 2: 400 µg of vaginal misoprostol every 3 h up to a maximum of five doses (vaginal regimen). <i>Results:</i> The induction-to-abortion interval was significantly longer in group 1 (25.5 ± 24.45 h) than in group 2 (15 ± 7.14 h) (p = 0.016). The abortion rate within 24 h in group 1 was of 56.8 vs. 85.7% in group 2 (p = 0.006). The hazard rate for vaginal delivery within 24 h was found to be 2.277-fold greater in the group with the combined therapy once controlled for plausible confounders. <i>Conclusions:</i> Our study suggests that oral misoprostol combined with vaginal misoprostol does not reduce the induction-to-abortion interval compared to an exclusively vaginal route when used for early 2nd-trimester pregnancy termination.