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Necrotic cell death and ‘necrostatins’: now we can control cellular explosion

2008; Elsevier BV; Volume: 33; Issue: 8 Linguagem: Inglês

10.1016/j.tibs.2008.05.007

1362-4326

Peter Vandenabeele, Wim Declercq, Tom Vanden Berghe,

interferon and immune responses

The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.