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BIBTEX RIS

Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone

2013; Multidisciplinary Digital Publishing Institute; Volume: 18; Issue: 3 Linguagem: Inglês

10.3390/molecules18032769

ISSN

1433-1373

Autores

Otemberg Chaves, Roosevelt Albuquerque Gomes, Anna Cláudia de Andrade Tomaz, Marianne Guedes Fernandes, Leônidas Das Graças Mendes, Maria de Fátima Agra, Valdir A. Braga, María de Fátima Vanderlei de Souza,

Tópico(s)

Biological Activity of Diterpenoids and Biflavonoids

Resumo

The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 173-ethoxypheophorbide A (4), 132-hydroxy phaeophytin B (5), 173-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by 1H- and 13C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.

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