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IBUPROFEN COMBINED WITH ANTIBIOTICS SUPPRESSES RENAL SCARRING DUE TO ASCENDING PYELONEPHRITIS IN RATS

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(05)68319-x

1527-3792

Andrew Huang, Lane S. Palmer, David B. Hom, Ann E. Anderson, Leslie Kushner, Israel Franco,

Urinary Tract Infections Management

No AccessJournal of UrologyPediatric Urology1 Oct 1999IBUPROFEN COMBINED WITH ANTIBIOTICS SUPPRESSES RENAL SCARRING DUE TO ASCENDING PYELONEPHRITIS IN RATS ANDREW HUANG, LANE S. PALMER, DAVID HOM, ANN E. ANDERSON, LESLIE KUSHNER, and ISRAEL FRANCO ANDREW HUANGANDREW HUANG , LANE S. PALMERLANE S. PALMER , DAVID HOMDAVID HOM , ANN E. ANDERSONANN E. ANDERSON , LESLIE KUSHNERLESLIE KUSHNER , and ISRAEL FRANCOISRAEL FRANCO View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68319-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In acute pyelonephritis renal scarring may be decreased by immediate antibiotic therapy. Unfortunately in children there is often a delay in starting treatment, which increases the likelihood of renal scarring. In rodents immediate antibiotic therapy is effective for preventing renal scar formation resulting from experimentally induced pyelonephritis. However, the same treatment beginning 72 hours after infection does not prevent renal scarring in this paradigm. We examined whether delayed administration of the nonsteroidal anti-inflammatory agent ibuprofen only or combined with antibiotics suppresses renal scarring in a model of ascending pyelonephritis in rats. Materials and Methods: An inoculum of 5 × 109 organisms per ml. of Escherichia coli strain BH-5 was instilled into the bladder of rats and the urethra was occluded for 4 hours. Groups of animals were and were not treated with 15 mg./kg. cefadroxil or 10 mg./kg. ibuprofen given twice daily for 5 days, or the 2 drugs combined. Treatment began 72 hours after inoculation. In an additional group of rats sterile phosphate buffered saline was instilled into the bladder. In each rat the kidneys were examined grossly and microscopically 6 weeks later. Results: Combined antibiotics and ibuprofen significantly inhibited gross renal scarring compared with no treatment or antibiotics only (p 0.05). Conclusions: Renal scarring resulting from acute pyelonephritis in this rat model is not decreased by delayed treatment with antibiotics only. The addition of ibuprofen to antibiotic therapy is effective for decreasing renal scarring due to acute pyelonephritis even when treatment is delayed for 72 hours. References 1 : Renal scarring after acute pyelonephritis. Arch. Dis. Child.1994; 70: 111. Google Scholar 2 : Longterm prognosis of post-infectious renal scarring in relation to radiological findings in childhood: a 27 year followup. Ped. Nephrol.1992; 6: 19. Google Scholar 3 : Etiology and pathophysiology of pyelonephritis. Amer. J. Kidney Dis.1991; 17: 1. Google Scholar 4 : Prevention of scarring in experimental pyelonephritis in the rat by early antibiotic therapy. Nephron1982; 30: 262. Google Scholar 5 : The inflammatory response and tissue damage. Ped. Nephrol.1987; 1: 615. Google Scholar 6 : Acquired renal scars in children. J. Urol.1983; 129: 1190. Link, Google Scholar 7 : Suppression of renal scarring by prednisolone combined with ciprofloxacin in ascending pyelonephritis in rats. J. Urol.1994; 151: 1078. Abstract, Google Scholar 8 : Effect of ebselen on renal scarring in rats following renal infection. Chemotherapy1995; 41: 208. Google Scholar 9 : Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats. J. Urol.1999; 161: 1681. Link, Google Scholar 10 : . New York: McGraw-Hill1996: 638. Google Scholar 11 : An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice. J. Med. Microbiol.1995; 43: 33. Google Scholar 12 : Role of superoxide in renal scarring following infection by mannose-sensitive piliated bacteria. Urol. Res.1991; 19: 229. Google Scholar 13 : Vesico-ureteric reflux and reflux nephropathy. Kidney Int.1993; 44: S80. Google Scholar 14 : Reflux nephropathy: the glomerular lesion and progression of renal failure. Ped. Nephrol.1993; 7: 365. Google Scholar 15 : Etiology of end stage renal disease requiring renal transplantation in children between 1987 to 1993. Ped. Clin. N. Amer.1995; 42: 1603. Google Scholar 16 : Reflux in renal scarring. Brit. J. Rad.1978; 51: 1. Google Scholar 17 : Vesicoureteral reflux and pyelonephritis in the monkey: a review. J. Urol.1992; 148: 1721. Link, Google Scholar 18 : Renal function after short-term ibuprofen use in infants and children. Pediatrics1997; 100: 954. Google Scholar From the Division of Pediatric Urology, Schneider Children's Hospital, Department of Pathology, Long Island Jewish Medical Center, New Hyde Park and Section of Pediatric Urology, New York Medical College, Valhalla, New York© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byFitzgerald J, Chou S, Franco I, Mooppan U, Kim H, Saini R and Gulmi F (2009) Atorvastatin Ameliorates Tubulointerstitial Fibrosis and Protects Renal Function in Chronic Partial Ureteral Obstruction CasesJournal of Urology, VOL. 182, NO. 4S, (1860-1868), Online publication date: 1-Oct-2009. Volume 162Issue 4October 1999Page: 1396-1398 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.Keywordskidneyrats, Sprague-Dawleypyelonephritisantibioticsanti-inflammatory agents, non-steroidalMetricsAuthor Information ANDREW HUANG More articles by this author LANE S. PALMER More articles by this author DAVID HOM More articles by this author ANN E. ANDERSON More articles by this author LESLIE KUSHNER More articles by this author ISRAEL FRANCO More articles by this author Expand All Advertisement PDF downloadLoading ...