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Specific airway conductance (SGaw) reflecting methacholine responsiveness is associated with BMI*1

2004; Elsevier BV; Volume: 113; Issue: 2 Linguagem: Inglês

10.1016/j.jaci.2004.01.742

1097-6825

Mark E. Rose, M S Kavuru, Alton L. Melton, Kate McCarthy, David M. Lang,

Voice and Speech Disorders

RATIONALE: During methacholine challenge (MC) a positive response is defined as a drop in FEV1 ≥20% or Specific Airway Conductance (SGAW) ≥35%.Changes in SGaw ≥35% in the absence of changes in FEV1 ≥20% have been reported.The purpose of this study was to identify characteristics of patients who experience ≥35% drop in SGaw.METHODS: From 1999-2003, both FEV1 and SGaw were measured in 567 patients who underwent methacholine challenge.A retrospective chart review was conducted and analysis of variance utilized to identify patient characteristics.RESULTS: Patients were divided into four groups based on their change in SGaw and FEV1: Group 1, FEV1 ≥20% and SGaw ≥35%, 147 patients; Group 2, FEV1 <20% and SGaw ≥35%, 123 patients; Group 3, FEV1 ≥20% and SGaw <35%, 75 patients; Group 4, FEV1 <20% and SGaw <35%, 222 patients.Average body mass index (BMI) for the four groups was 28.9, 30.6, 27.4,26.8.The increased BMI found in patients with a drop in SGaw ≥35% was statistically significant (p<0.001).The change in BMI was independent of race, gender, or presenting history.CONCLUSIONS: Patients who experience decline in SGaw ≥35% during MC have increased BMI compared to patients with no significant change in SGaw.Our data suggest SGaw measurement should be performed for patients with increased BMI undergoing MC.