Produção Nacional
Revisado por pares
Pituitary–gonadal hormones and interleukin patterns in leprosy
2006; Wiley; Volume: 11; Issue: 9 Linguagem: Inglês
10.1111/j.1365-3156.2006.01692.x
ISSN1365-3156
AutoresA.M.O. Leal, Patrícia Künzle Ribeiro Magalhães, Cacilda da Silva Souza, Norma Tiraboschi Foss,
Tópico(s)Dermatology and Skin Diseases
ResumoSummary The functional status of pituitary–gonadal hormones and their relationship to the pattern of inflammatory cytokines in the lepromatous (LL/BL) and tuberculoid (TT/BT) poles of leprosy were investigated. Gonadotropins [luteinizing hormone (LH) and follicle‐stimulating hormone (FSH)], interleukin (IL)‐1 β , IL‐6, tumour necrosis factor (TNF)‐ α and C‐reactive protein (CRP) concentrations and erythrocyte sedimentation rate (ESR) were significantly higher in LL/BL leprosy patients than in controls and were not different from controls in TT/BT patients. LH and FSH were positively correlated with IL‐1 β , IL‐6 and TNF‐ α , and CRP concentrations and ESR. Testosterone plasma levels were significantly decreased in LL/BL patients and not different in TT/BT patients compared with controls. In addition, testosterone levels were inversely correlated with IL‐6 and TNF‐ α . Prolactin plasma levels of both LL/BL and TT/BT patients were not different when compared with those of controls. There was a significant positive correlation between IL‐6 and TNF‐ α plasma levels and ESR and CRP concentrations. IL‐1 β was positively correlated with ESR but not with CRP. The significant correlations between gonadotropins and testosterone and cytokines in leprosy patients suggest that cytokines may have a direct influence at testicular level and may be of pathogenetic significance in leprosy and in other inflammatory states involving reproductive dysfunction.
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