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Localization of MCT 2 at peroxisomes is associated with malignant transformation in prostate cancer

2015; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês

10.1111/jcmm.12481

1582-4934

Isabel Valença, Nelma Pértega‐Gomes, José R. Vizcaíno, Rui Henrique, Carlos Lopes, Fátima Baltazar, Daniela Ribeiro,

Cancer, Lipids, and Metabolism

Abstract Previous studies on monocarboxylate transporters expression in prostate cancer ( PCa ) have shown that monocarboxylate transporter 2 ( MCT 2) was clearly overexpressed in prostate malignant glands, pointing it out as a putative biomarker for PCa . However, its localization and possible role in PCa cells remained unclear. In this study, we demonstrate that MCT 2 localizes mainly at peroxisomes in PCa cells and is able to take advantage of the peroxisomal transport machinery by interacting with Pex19. We have also shown an increase in MCT 2 expression from non‐malignant to malignant cells that was directly correlated with its peroxisomal localization. Upon analysis of the expression of several peroxisomal β‐oxidation proteins in PIN lesions and PCa cells from a large variety of human prostate samples, we suggest that MCT 2 presence at peroxisomes is related to an increase in β ‐oxidation levels which may be crucial for malignant transformation. Our results present novel evidence that may not only contribute to the study of PCa development mechanisms but also pinpoint novel targets for cancer therapy.